Effects of weight loss on testosterone, sex hormone‐binding globulin, adiposity, and insulin sensitivity in women and men
Authors' conclusion
BioA testosterone was associated with Rd, positively in men and negatively in women. Weight loss reduced BioA testosterone in women; however, individual changes were associated with improved Rd in men. SHBG was a better correlate of improved Rd in women. Additional studies should identify mechanisms that drive sex differences and interventions that modify testosterone, reduce adiposity, and improve Rd across both sexes.
Study context
- Population
- Adult men and women, BMI 20–41 kg/m²; men and women with obesity completed a 16-week dietary weight-loss program (n = 17/15)17/15 with obesity completed weight loss
- Participants
- 27 vs 28
- Exposure
- Men vs women, with and without obesity, before and after weight loss
- Menn = 27
- Womenn = 28
- Outcome
- Associations of BioA testosterone and SHBG with glucose disposal (Rd)
Methodological details16-week dietary weight-loss program
- 16-week dietary weight-loss program
Main finding
As reported in the abstract
- Bioavailable (BioA) testosterone related to Rd positively in men and negatively in women
- p < 0.05
Observational data: associations, not effects.
Further findings
Effects of weight loss · 16 weeks
- Across participants, weight loss increased Rd and sex hormone-binding globulin (SHBG)
- P < 0.01
- Men: BioA testosterone unchanged; individual changes independently related to Rd
- P = 0.031
- Women: BioA testosterone declined, not related to Rd
- P < 0.009
Original publication
Effects of weight loss on testosterone, sex hormone‐binding globulin, adiposity, and insulin sensitivity in women and men. Obesity (Silver Spring). Published 1 April 2025. doi:10.
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