Mediterranean Diet, Physical Activity, and Bone Health in Older Adults: A Secondary Analysis of a Randomized Clinical Trial
Primary result · Lumbar spine (L1-L4) BMD, mean changeResult — go to the resultBetween-group difference 0.9 g/cm² 95% CI 0.1–1.8Authors' conclusion
In the PREDIMED-Plus trial, an energy-reduced Mediterranean diet and physical activity lifestyle intervention mitigated weight loss- and age-related BMD decline among older women with metabolic syndrome compared with conventional ad libitum Mediterranean diet recommendations.
Study context
- Population
- Men and women aged 55–75 years with metabolic syndrome and overweight or obesity, with access to DXA, 4 centres in Spain454 women · 470 men
- Participants
- 924 participants
- Comparison
- Energy-reduced Mediterranean diet plus increased physical activity vs ad libitum Mediterranean diet without physical activity promotion
- Interventionn = 460
- Controln = 464reference
- Primary endpoint
- BMD (total femur, lumbar spine [L1-L4], femoral trochanter), total BMC and low BMD prevalence by DXA
- Follow-up
- 1 and 3 years
Methodological detailsprespecified secondary analysis, parallel-group, 3-year
- Prespecified secondary analysis
- Parallel-group
- 3-year
Primary result
Lumbar spine (L1-L4) BMD, mean change · 3 years
Between-group difference
0.9 g/cm²
95% CI 0.1–1.8
overall P = .05
Interventionvs Control
between-group difference 0.9 g/cm² (95% CI 0.1–1.8); overall P = .05
As reported in the abstract
Further findings
| Outcome | Between-group difference (g/cm²) (95% CI) | P value | |
|---|---|---|---|
| Lumbar spine (L1-L4) BMD, women (subgroup) · 3 yearsAfter 1 year: −0.1 (95% CI −1.3 to 1.1) g/cm² | 1.8 (0.6–2.9) | overall P = .005 | |
| −2024Difference, g/cm² (linear scale) |
Lumbar spine bone mineral density (BMD), men (subgroup)
- Protective association not observed for men
Total bone mineral content (BMC) and low BMD prevalence · 3 years
- No overall 3-year intervention effect
Original publication
Mediterranean Diet, Physical Activity, and Bone Health in Older Adults: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. Published 1 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →