Association between delay in diabetes development and mortality in people with obesity: Up to 33 years follow‐up of the prospective Swedish Obese Subjects study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.60 95% CI 1.19–2.15Authors' conclusion
A 2-year delay in diabetes development may be linked to increased life expectancy, possibly due to a reduction in cardiovascular mortality. Future studies should confirm these findings.
Study context
- Population
- Participants with obesity from the Swedish Obese Subjects study without diabetes at baseline and known diabetes status at 2-year follow-up: bariatric surgery and usual obesity care140 of diabetes from usual care · bariatric surgery 1,471 · usual obesity care 1,392
- Participants
- 146 vs 2,717
- Exposure
- Newly diagnosed T2D at 2-year follow-up vs remained diabetes-free
- Diabetesn = 146
- Diabetes-freen = 2,717reference
- Outcome
- Mortality / life expectancy
- Follow-up
- Median 26.1 years (IQR 22.7-28.7 years)
Methodological detailssecondary analysis of the Swedish Obese Subjects study, adjusted for inclusion year, sex, baseline age, body mass index (BMI) and smoking, Cause of death from the Swedish Cause of Death Register, case sheets and autopsy reports
- Secondary analysis of the Swedish Obese Subjects study
- Adjusted for inclusion year, sex, baseline age, BMI and smoking
- Cause of death from the Swedish Cause of Death Register, case sheets and autopsy reports
Main finding
All-cause mortality · median follow-up 26.1 years
Adjusted hazard ratio
1.60
95% CI 1.19–2.15
P = 0.002
By group
Diabetes
18.3 deaths per 1000 person-years
95% CI 14.1–23.9
Diabetes-free
10.9 deaths per 1000 person-years
95% CI 10.2–11.8
Diabetesvs Diabetes-free
aHR 1.60 (95% CI 1.19–2.15); P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (years) (95% CI) | P value | |
|---|---|---|---|
| Adjusted median life expectancyShorter with Diabetes | 3.7 (1.4–6.0) | P = 0.002 | |
| −50510Difference, years (linear scale) |
| Outcome | Adj sub-HR (95% CI) | P value | |
|---|---|---|---|
| Cardiovascular mortality | 1.74 (1.09–2.77) | P = 0.021 | |
| 0.20.5125Adj sub-HR (log scale) |
Original publication
Association between delay in diabetes development and mortality in people with obesity: Up to 33 years follow‐up of the prospective Swedish Obese Subjects study. Diabetes Obes Metab. Published 21 October 2024. doi:10.
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