The effect of sarcopenic obesity on glycaemic status based on fasting plasma glucose and glycated haemoglobin: A prospective cohort study
Main finding · Progression from normoglycaemia to DMResult — go to the resultAdjusted hazard ratio 2.11 95% CI 1.10–4.04Authors' conclusion
The effect of sarcopenic obesity on the progression of glycaemic status based on fasting plasma glucose and glycated haemoglobin may be more pronounced than that of sarcopenia only or obesity only.
Study context
- Population
- Middle-aged and older adults without DM, China Health and Retirement Longitudinal Study 2011–2015; mean age 58.98 ± 8.82 years, 45.35% men
- Participants
- 4,637 participants
- Exposure
- Sarcopenic obesity, sarcopenia only or obesity only vs neither sarcopenia nor obesity
- Outcome
- Progression of glycaemic status (ADA criteria, FPG and HbA1c)
Methodological detailsChina Health and Retirement Longitudinal Study 2011-2015, Cox proportional hazard models
- China Health and Retirement Longitudinal Study 2011-2015
- Cox proportional hazard models
Main finding
Progression from normoglycaemia to DM
Adjusted hazard ratio
2.11
95% CI 1.10–4.04
Sarcopenic obesityvs Without sarcopenia and obesity
aHR 2.11 (95% CI 1.10–4.04)
As reported in the abstract
- Glycaemic status progression over 18,497 person-years
- 1743 (37.59%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Progression from prediabetes to DMSarcopenic obesityvs Without sarcopenia and obesity | 1.65 (1.04–2.63) | |
| Progression from prediabetes to DMSarcopenia onlyvs Without sarcopenia and obesity | 1.78 (1.11–2.86) | |
| Progression from prediabetes to DMObesity onlyvs Without sarcopenia and obesity | 2.00 (1.29–3.12) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
The effect of sarcopenic obesity on glycaemic status based on fasting plasma glucose and glycated haemoglobin: A prospective cohort study. Diabetes Obes Metab. Published 21 October 2024. doi:10.
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