The relationship between leptin-to-adiponectin ratio and HOMA-IR and metabolic syndrome in five African-origin populations
Authors' conclusion
Our study suggests that individuals of the African diaspora in different geographical locations may differ in the determinants of MS. Future studies should investigate the determinants for the disparate relationships between MS, IS and adipokines across different African-origin populations.
Study context
- Population
- Adults of African origin in Ghana, South Africa, Jamaica, Seychelles and US; metabolic syndrome by Harmonized criteria
- Participants
- 2,087 adults
- Exposure
- Ghana vs South Africa vs Jamaica vs Seychelles vs US
- Outcome
- Associations of serum leptin, adiponectin and leptin-to-adiponectin (L/A) ratio with metabolic syndrome (MS) and HOMA-IR
Methodological detailsmultisite
- Multisite
Main finding
As reported in the abstract
Associations of L/A ratio, leptin and adiponectin with MS and HOMA-IR, adjusted for age, sex and fat mass
- L/A ratio, unlike HOMA-IR, associated with metabolic syndrome (MS) across all sites
- p < 0.001
- Within sites, L/A ratio associated with MS only in US
- p < 0.001
- Within sites, L/A ratio associated with HOMA-IR only in South Africa
- p < 0.01
- Leptin associated with MS in South Africa only
- p < 0.05
- Leptin associated with HOMA-IR across all five sites and within US
- p < 0.05
- Adiponectin associated with HOMA-IR in South Africa
- p < 0.05
- Adiponectin associated with MS across all five sites
- p < 0.001
Observational data: associations, not effects.
Original publication
The relationship between leptin-to-adiponectin ratio and HOMA-IR and metabolic syndrome in five African-origin populations. Int J Obes (Lond). Published 17 October 2024. doi:10.
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