Dual Energy X‐Ray Absorptiometry Reveals Differential Glycemic Implications of Adiposity in Underweight, Normal Weight, and Overweight South African Women With Newly‐Diagnosed Diabetes
Authors' conclusion
In young South African women with newly-diagnosed diabetes, adiposity relates to A1c only in those who are underweight, but paradoxically not in those with normal weight or overweight/obesity, potentially suggestive of biologic differences from diabetes in other populations.
Study context
- Population
- Young women with previously undiagnosed diabetes in Soweto, South Africa (median age 22.4 years; median A1c 7.0%); DXA scanning of total and regional adiposity
- Participants
- 379 women
- Exposure
- Underweight vs normal weight vs overweight/obese BMI categories
- Overweight/obesen = 192
- Normal weightn = 158
- Underweightn = 29
- Outcome
- Association of adiposity (DXA) with A1c by BMI category
Methodological detailsbaseline assessment for a trial
- Baseline assessment for a trial
Main finding
As reported in the abstract
Underweight, adjusted: fat mass associated with A1c
β = 0.18
p = 0.007
Underweight, adjusted: gynoid fat associated with A1c
β = 0.77
p = 0.03
Underweight, adjusted: trunk fat associated with A1c
β = 0.46
p = 0.01
Underweight, adjusted: leg fat associated with A1c
β = 0.30
p = 0.01
Observational data: associations, not effects.
Further findings
Body composition and A1c across BMI categories
- All body composition measures progressively increased from underweight to normal weight to overweight/obese (all p < 0.001)
- A1c did not differ between the groups
Original publication
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