A comparison of associations of body mass index and dual‐energy x‐ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women
Authors' conclusion
BMI can be a good proxy for DXA measured %FAT and TOTFAT in descriptive metabolomic studies of healthy, young White women. Larger studies in more diverse populations are needed to endorse more generalized conclusions.
Study context
- Population
- Women aged 25 to 29 years in the Dietary Intervention Study in Children Follow-Up Study
- Participants
- 202 women
- Exposure
- Body mass index (BMI) vs DXA-measured %FAT and TOTFAT as adiposity measures in serum metabolomics
- Outcome
- Partial correlations of adiposity measures with log-transformed serum metabolites
Main finding
As reported in the abstract
Metabolites correlated with BMI, %FAT and/or TOTFAT (significant overlap)
93
Metabolites differently correlated with BMI vs %FAT
9
Metabolites differently correlated with BMI vs TOTFAT
15
Observational data: associations, not effects.
Further findings
Metabolite set enrichment analysis
- Diacylglycerol and sphingolipid metabolism overrepresented among metabolites significantly correlated with all three adiposity measures
Original publication
A comparison of associations of body mass index and dual‐energy x‐ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women. Obesity (Silver Spring). Published 15 January 2023. doi:10.
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