Development and Application of Children's Sex‐ and Age‐Specific Fat‐Mass and Muscle‐Mass Reference Curves From Dual‐Energy X‐Ray Absorptiometry Data for Predicting Cardiometabolic Risk
Authors' conclusion
Results suggest that phenotypes based on fat and muscle mass may have clinical utility in children and should be further investigated.
Study context
- Population
- Children ≤17 years in NHANES (reference curves); QUALITY cohort children aged 8–10 years in 2005 (application)QUALITY cohort
- Participants
- 630 children
- Exposure
- DXA-derived fat-mass/muscle-mass phenotypes vs LA-HM reference
- Outcome
- Cardiometabolic risk markers (HDL, TG, HOMA-IR) by phenotype
- Follow-up
- Baseline and first
Methodological detailsreference curve development (NHANES DXA data, Lambda Mu Sigma method), application to QUALITY cohort, adjusted for age, sex and Tanner's stage, Reference curves from NHANES DXA data (n = 6120)
- Reference curve development (NHANES DXA data, Lambda Mu Sigma method)
- Application to QUALITY cohort
- Adjusted for age, sex and Tanner's stage
- Reference curves from NHANES DXA data (n = 6120)
Main finding
As reported in the abstract
- HA-HM vs LA-HM: less favourable HDL, TG and HOMA-IR at baseline and first follow-up, but not in their changes
- HA-LM vs LA-HM: less favourable HOMA-IR at baseline and first follow-up
Observational data: associations, not effects.
Original publication
Development and Application of Children's Sex‐ and Age‐Specific Fat‐Mass and Muscle‐Mass Reference Curves From Dual‐Energy X‐Ray Absorptiometry Data for Predicting Cardiometabolic Risk. Pediatr Obes. Published 29 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →