Effects of various exercise types on inflammatory response in individuals with overweight and obesity: a systematic review and network meta-analysis of randomized controlled trials
Authors' conclusion
This study highlights the potential of exercise in alleviating the inflammatory status in IOO, with different exercise types showing various effects on specific inflammatory biomarkers. The intensity and duration of exercise had a dose-response relationship with intervention effectiveness. Changes in body composition correlated with the effectiveness of the intervention. COM, AE, and HIIT are recommended exercise approaches.
Study context
- Population
- Individuals with overweight and obesity (IOO)123 RCTs
- Comparison
- Exercise types on inflammatory biomarkers
- Outcome
- Inflammatory biomarkers (leptin, CRP, adiponectin, IL-6, TNF-α, IL-10)
Methodological detailsRCTs in English, January 2000–August 2023, meta-regression, subgroup analyses
- RCTs in English, January 2000–August 2023
- Meta-regression
- Subgroup analyses
Pooled result
As reported in the abstract
Inflammatory biomarkers
- Different exercise types yielded distinct effects on various inflammatory biomarkers
- COM and aerobic exercise (AE) most effective for improving leptin
- AE most effective in reducing CRP and increasing adiponectin
- High-intensity interval training (HIIT) most effective for ameliorating IL-6, TNF-α and IL-10
- Resistance training (RT) had the least effect vs other exercise types
Further pooled results
Meta-regression and subgroup analyses
- High-intensity AE had a greater effect size than moderate-intensity AE
- AE effect on IL-10 positively associated with training period and participant age
- Body fat reductions positively correlated with effect sizes of CRP, TNF-α and IL-10
- Gender influenced AE effects on IL-6 and TNF-α; females responded better
Original publication
Effects of various exercise types on inflammatory response in individuals with overweight and obesity: a systematic review and network meta-analysis of randomized controlled trials. Int J Obes (Lond). Published 17 October 2024. doi:10.
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