Role of Planetary Health Diet in the association between genetic susceptibility to obesity and anthropometric measures in adults
Authors' conclusion
Diet quality assessed with the PHD did not mediate or moderate the associations between genetic susceptibility to obesity and anthropometric measures. This lack of effect may be partly due to low adherence to the PHD and the older age of participants ( > 50 years) at baseline.
Study context
- Population
- Adults from a Finnish population-based cohort (54% women, mean age 53 (SD ± 13) years)replication cohort 2,834
- Participants
- 2,942 adults
- Exposure
- Mediating and moderating role of the Planetary Health Diet (PHD) in the association between polygenic risk score (PRS) for body mass index (BMI) and anthropometric measures
- Outcome
- Mediation or moderation by the PHD of the association between genetic susceptibility to obesity (PRS for BMI) and anthropometric measures (weight, height, WC, body fat percentage)
- Follow-up
- Baseline and changes over 7 years
Methodological detailsreplication in a second Finnish cohort
- Replication in a second Finnish cohort
Main finding
As reported in the abstract
- PRS for BMI positively associated with baseline BMI and changes in anthropometric measures, except waist circumference (WC)
- p = 0.12
- Association with baseline BMI and WC
- p < 0.001
- Association with changes in BMI and WC
- p = 0.01
- Association with body fat percentage change
- p = 0.05
- PHD average score
- 3.8 points
Observational data: associations, not effects.
Further findings
- Findings consistent in the replication cohort
Original publication
Role of Planetary Health Diet in the association between genetic susceptibility to obesity and anthropometric measures in adults. Int J Obes (Lond). Published 17 October 2024. doi:10.
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