Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children
Authors' conclusion
The results suggest children with the FTO rs9939609 risk allele may be predisposed to excess consumption of candy and that this association may be exacerbated by food cues.
Study context
- Population
- Children aged 9–12 yearscrossover
- Participants
- 177 children
- Comparison
- Obesity-associated genotypes (FTO rs9939609, MC4R rs571312, paediatric polygenic risk score (PRS)) in relation to eating in the absence of hunger (EAH); food vs non-food advertisements as effect modifier
Methodological detailsrandomized crossover, eating in the absence of hunger paradigm, Linear mixed-effects models; effect modification tested with multiplicative interaction terms
- Randomized crossover
- Eating in the absence of hunger paradigm
- Linear mixed-effects models; effect modification tested with multiplicative interaction terms
Primary result
As reported in the abstract
Gummy candy EAH per FTO risk allele
Increase in gummy candy EAH per FTO risk allele (adjusted models)
30%
p = 0.025
Further findings
Effect modification by food cues: FTO variant and gummy candy EAH
- Food cue exposure exacerbated associations between FTO variant and gummy candy EAH
- P = 0.046
MC4R and EAH
- No statistically significant associations between MC4R and EAH
Original publication
Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children. Pediatr Obes. Published 28 August 2024. doi:10.
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