The Use of Body Mass Index Polygenic Risk Score ( BMI ‐ Polygenic Risk Scores (PRS) ) in a Paediatric Population With Obesity
Authors' conclusion
In a genetically enriched clinical cohort, polygenic scores lose discriminatory power, delineating their optimal use for population screening rather than intra-clinic risk stratification.
Study context
- Population
- European adolescents with overweight and obesity (mean ± SD age 13.3 ± 2.2 years; 51% female; BMI 31.6 ± 4.1 kg/m²), tertiary clinic, Salzburg, Austria
- Participants
- 246 vs 2,044
- Exposure
- Adolescents with overweight/obesity in a tertiary clinic vs population-based adult cohort (BMI-PRS distribution)
- Adolescentsn = 246
- Adultn = 2,044reference
- Outcome
- BMI-PRS (PGS000027) distribution and association with BMI
Methodological detailssingle-centre, tertiary clinic, comparison with population-based adult cohort
- Single-centre
- Tertiary clinic
- Comparison with population-based adult cohort
Main finding
As reported in the abstract
Within the clinic sample, BMI-PRS correlation with BMI (r)
−0.11; 95% CI −0.23 to 0.02
Observational data: associations, not effects.
Further findings
- PRS for HOMA-IR and T2D showed similarly null associations
Original publication
The Use of Body Mass Index Polygenic Risk Score ( BMI ‐ PRS ) in a Paediatric Population With Obesity. Pediatr Obes. Published 1 July 2026. doi:10.
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