Physical Activity and Incident Obesity Across the Spectrum of Genetic Risk for Obesity
Authors' conclusion
In this cohort study, the association between daily step count and obesity risk across genetic background and baseline BMI were quantified. Population-based recommendations may underestimate physical activity needed to prevent obesity among those at high genetic risk.
Study context
- Population
- US All of Us Research Program enrollees of European ancestry with a personal activity tracker and without obesity up to 6 months into tracking, enrolled May 2018–July 2022; 73% women, median age 52.7 years
- Participants
- 3,124 participants
- Exposure
- Genetic risk and daily step count in relation to incident obesity
- Outcome
- Incident obesity (BMI ≥30)
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
P = 1.0 × 10-20
- Body mass index (BMI) polygenic risk score (PRS), 75th vs 25th percentile: increase in obesity risk
- 81% (P = 3.57 × 10-20)
- Mean step count, 75th vs 25th percentile: reduction in obesity risk
- 43% (P = 5.30 × 10-12)
Observational data: associations, not effects.
Further findings
Additional steps/d needed at PRS 75th percentile for risk comparable to 50th percentile
- Mean additional steps/d (11 020 total)
- 2280 (95% CI, 1680-3310)
Additional steps/d needed at PRS 75th percentile for risk comparable to 25th percentile, by baseline BMI
Steps/d
- Baseline BMI 22
- 3460
- Baseline BMI 24
- 4430
- Baseline BMI 26
- 5380
- Baseline BMI 28
- 6350
Daily step count, total cohort · median 5.4 (IQR, 3.4-7.0) years of tracking
- Median steps/d
- 8326 (IQR, 6499-10 389)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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