Plasma proteomic profile of abdominal obesity in older adults
Authors' conclusion
The study unveiled a multifaceted plasma proteomic profile of abdominal obesity in older adults, offering insights into its wide-ranging impact on the proteome. It also elucidated novel proteins, clusters of correlated proteins, and pathways that are intricately associated with abdominal obesity.
Study context
- Population
- Ashkenazi Jewish adults aged ≥65 years (LonGenity cohort); mean (SD) age 75.7 (6.7) years, 55.4% women
- Participants
- 969 adults
- Outcome
- Association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins
Methodological detailsproteomic analysis, SomaScan Assay, LonGenity cohort
- Proteomic analysis
- SomaScan Assay
- LonGenity cohort
Main finding
As reported in the abstract
Plasma proteins associated with WC
- Proteins associated with WC in the linear regression model
- 480 of 4265
- Leptin, β (SE)
- 12.363 (0.490)
- INHBC, β (SE)
- 24.324 (1.448)
- IGFBP-2, β (SE)
- −12.782 (0.841)
- H6ST3, β (SE)
- −39.995 (2.729)
- MXRA8, β (SE)
- −27.101 (1.850)
Observational data: associations, not effects.
Further findings
Pathway analysis
- Cell adhesion, extracellular matrix remodeling and IGF transport were the top enriched pathways associated with WC
Proteomic WC signature (elastic net regression)
- Correlation with measured WC, r
- 0.80
- Signature associated with various metabolic and physical traits
Original publication
Plasma proteomic profile of abdominal obesity in older adults. Obesity (Silver Spring). Published 4 March 2024. doi:10.
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