Changes in plasma levels of a selected panel of microRNAs (miRNAs) do not explain the shift from cholesterol-synthesizer to cholesterol-absorber phenotype in men with abdominal obesity after diet-induced weight loss
Authors' conclusion
In men with abdominal obesity, these five plasma miRNAs did not contribute to the observed phenotype switch from cholesterol-synthesizer towards cholesterol-absorber following weight loss.
Study context
- Population
- Men with abdominal obesity; screening from existing database, highest and lowest plasma lathosterol/campesterol ratiosexisting database 367 · highest 8 · lowest 8
- Participants
- 23 vs 26
- Comparison
- Diet-induced weight loss vs no weight loss
- Weight lossn = 23
- Controln = 26reference
- Primary endpoint
- Changes in plasma levels of pre-selected miRNAs (mediation of cholesterol-synthesizer to cholesterol-absorber phenotype switch)
- Follow-up
- Pre- and post-intervention
Methodological detailspreceded by untargeted serum miRNA screening
- Preceded by untargeted serum miRNA screening
Primary result
As reported in the abstract
Change in plasma miRNA levels (5 miRNAs) · pre- to post-intervention
- Changes in plasma miRNA levels were not significantly different between the two groups
- Expected phenotype shift after weight loss was observed
Further findings
Screening: miRNAs associated with phenotypes
- Cholesterol-synthesizer: miR-486-5p, miR-320b-3p, miR-185-5p; cholesterol-absorber: miR-4529-3p, miR-3613-5p, miR-6776-5p
- miR-4529-3p assay unreliable and excluded
Original publication
Changes in plasma levels of a selected panel of miRNAs do not explain the shift from cholesterol-synthesizer to cholesterol-absorber phenotype in men with abdominal obesity after diet-induced weight loss. Int J Obes (Lond). Published 15 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →