Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high‐density lipoprotein cholesterol ratio in youths
Authors' conclusion
In youths with obesity, an elevated TG/HDL ratio is associated with high concentrations of proatherogenic lipoprotein subclasses. This phenotype may explain the increased cardiovascular risk associated with a high TG/HDL ratio.
Study context
- Population
- Adolescents with overweight/obesity (age 13 ± 3 years, 58% females, BMI z score 2.1 ± 0.8), phenotyped with 3-hour OGTT and abdominal MRI
- Participants
- 592 adolescents
- Exposure
- Highest vs lowest triglyceride (TG)/HDL quartile
- Outcome
- Lipoprotein particle concentration (proton NMR)
Methodological detailsmultiethnic cohort
- Multiethnic cohort
Main finding
As reported in the abstract
- Very low-density lipoprotein (VLDL) particle concentration, highest vs lowest TG/HDL quartile
- +178%, p < 0.0001
- Intermediate-density lipoprotein particle concentration, highest vs lowest quartile
- +338%, p < 0.0001
- Low-density lipoprotein (LDL) particle concentration, highest vs lowest quartile
- +42%, p < 0.0001
- TG/HDL correlation with VLDL particle size
- r = 0.37, p < 0.0001
- TG/HDL correlation with LDL particle size
- r = −0.51, p < 0.0001
- TG/HDL correlation with HDL particle size
- r = −0.69, p < 0.0001
Observational data: associations, not effects.
Original publication
Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high‐density lipoprotein cholesterol ratio in youths. Obesity (Silver Spring). Published 25 May 2023. doi:10.
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