Psychiatric Safety of GLP ‐1 and Dual GIP / GLP ‐1 Receptor Agonists in Adolescents With Obesity
Main finding · Suicide-related eventsResult — go to the resultHazard ratio 0.74 95% CI 0.57–0.95Authors' conclusion
Among adolescents with obesity, incretin-based therapy was not associated with increased psychiatric risk and was associated with lower risks of suicide-related events, suicidal ideation, and anxiety compared with lifestyle intervention.
Study context
- Population
- Adolescents with overweight or obesitypropensity score matched
- Participants
- 9,222 vs 9,222
- Exposure
- Incretin-based therapy vs lifestyle intervention
- Incretin-based therapyn = 9,222
- Lifestyle interventionn = 9,222reference
- Outcome
- Suicide-related events:
- Suicidal ideation
- Suicide attempt
- Follow-up
- 30 days to 1095 days after the index date
Methodological detailspropensity score matching, TriNetX Global Collaborative Network electronic health records
- Propensity score matching
- TriNetX Global Collaborative Network electronic health records
Main finding
Suicide-related events
Hazard ratio
0.74
95% CI 0.57–0.95
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Suicidal ideation · 30 to 1095 days after index datePropensity score matched | 0.73 (0.56–0.96) | |
| Anxiety · 30 to 1095 days after index datePropensity score matched | 0.92 (0.84–0.99) | |
| 0.512Hazard ratio (log scale) |
Suicide attempt, insomnia, depression and eating disorders · 30 to 1095 days after index date
- No significant differences for suicide attempt, insomnia, depression or eating disorders
Suicide-related events, female adolescents (subgroup)
- Risk reduction significant among female adolescents: HR
- 0.61 (0.46-0.82) (95% CI)
Suicide-related events, adolescents without T2D (subgroup)
- Risk reduction significant among those without T2D: HR
- 0.63 (0.47-0.85) (95% CI)
Suicide-related events, males and those with T2D (subgroups)
- Risk reductions not significant among males or those with T2D
Sensitivity analyses
- Sensitivity analyses supported the primary findings
Original publication
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