Handgrip Strength and Trajectories of Preclinical Obesity Progression: A Multistate Model Analysis Using the UK Biobank
Main finding · Preclinical obesity progression: baseline to first dysfunction (strongest association)Result — go to the resultHazard ratio 0.86 95% CI 0.85–0.88Authors' conclusion
Increased grip strength was significantly associated with a decreased risk of obesity-induced dysfunctions progression and multiple-cause mortality. These findings underscore the importance of improving muscle mass and strength in preclinical obesity.
Study context
- Population
- UK Biobank participants with preclinical obesity (elevated BMI plus ≥1 abnormal waist circumference, WHR, waist-to-height ratio or % body fat, without obesity-induced dysfunctions)8,163 deaths
- Participants
- 93,275 participants
- Exposure
- Higher vs lower grip strength
- Outcome
- Preclinical obesity progression (baseline to dysfunctions and death) and multiple-cause mortality
- Follow-up
- Mean 13.4 years
Methodological detailsmultistate model, UK Biobank
- Multistate model
- UK Biobank
Main finding
As reported in the abstract
Preclinical obesity progression: baseline to first dysfunction (strongest association)
Hazard ratio
0.86
95% CI 0.85–0.88
Per SD increase in grip strength
HR 0.86 (95% CI 0.85–0.88)
Per SD increase in grip strength, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Double dysfunctions to all-cause death (most pronounced association)Highest tertilevs Lowest tertileFully adjusted | 0.77 (0.70–0.84) | |
| 0.512Hazard ratio (log scale) |
Double dysfunctions to all-cause death (most pronounced association)
- Highest vs lowest tertile protective across all trajectory models
Subgroup and sensitivity analyses (free muscle volume, total lean mass, muscle-to-weight ratio)
- Consistent results
Original publication
Handgrip Strength and Trajectories of Preclinical Obesity Progression: A Multistate Model Analysis Using the UK Biobank. J Clin Endocrinol Metab. Published 15 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →