Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity
Authors' conclusion
These findings demonstrate significant molecular alterations in the VAT proteome associated with severe obesity, providing insights into the underlying mechanisms of metabolic disease. The differentially expressed proteins may serve as biomarkers or therapeutic targets for obesity-related complications.
Study context
- Population
- Individuals with severe obesity undergoing metabolic bariatric surgery and healthy controls undergoing elective abdominal surgery
- Participants
- 46 vs 17
- Exposure
- Severe obesity vs healthy controls
- Severe obesityn = 46
- Healthy controlsn = 17reference
- Outcome
- VAT proteome and its association with serum metabolic biomarkers
Methodological detailsproteomics (LC-MS/MS), NMR-based serum metabolomics
- Proteomics (LC-MS/MS)
- NMR-based serum metabolomics
Main finding
As reported in the abstract
Differentially expressed VAT proteins (FDR < 0.05) in severe obesity
Differentially expressed proteins in visceral adipose tissue (VAT)
22
Downregulated in severe obesity
12
Upregulated in severe obesity
10
Observational data: associations, not effects.
Original publication
Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity. Obesity (Silver Spring). Published 12 October 2025. doi:10.
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