Differential associations of subcutaneous and visceral fat with bone turnover markers: A study on bariatric surgery patients with severe obesity and individuals without obesity
Authors' conclusion
The findings suggest a specific interaction between intraperitoneal, extraperitoneal, and total visceral compartments and bone metabolism following RYGB. These observed relationships highlight the need for clinicians to consider regional fat distribution when assessing bone health in post-MBS patients.
Study context
- Population
- Individuals with severe obesity undergoing metabolic and bariatric surgery (MBS), and healthy individuals without obesity46 with severe obesity, 25 controls
- Participants
- 25 / 21 / 25
- Exposure
- Sleeve gastrectomy (SG) vs RYGB; patients with severe obesity vs controls without obesity
- SGn = 25
- RYGBn = 21
- Controlsn = 25reference
- Outcome
- Associations of regional fat compartments (abdominal and femoral SF, intraperitoneal, extraperitoneal and total VF) with circulating BTM levels
- Follow-up
- 6 months after MBS
Methodological detailsbefore and 6 months after MBS, MRI-quantified regional fat depots, FDR-adjusted p-values
- Before and 6 months after MBS
- MRI-quantified regional fat depots
- FDR-adjusted p-values
Main finding
As reported in the abstract
Associations of fat depots with BTMs
- SG: femoral subcutaneous fat (SF) inversely associated with cOC levels, vs RYGB
- p < 0.05
- RYGB: extraperitoneal, intraperitoneal and total visceral fat (VF) significantly associated with TotalOC, vs SG
- p < 0.05
- RYGB: intraperitoneal and total VF negatively associated with ucOC, vs SG
- p < 0.05
Observational data: associations, not effects.
Further findings
Pooled baseline associations of fat depots with bone turnover markers (BTMs)
- No significant associations between fat depots and BTMs
- all p > 0.05
Original publication
Differential associations of subcutaneous and visceral fat with bone turnover markers: A study on bariatric surgery patients with severe obesity and individuals without obesity. Int J Obes (Lond). Published 26 August 2025. doi:10.
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