Adenovirus 36 seropositivity is related to the expression of anti-adipogenic lncRNAs GAS5 and MEG3 in adipose tissue obtained from subjects with obesity
Authors' conclusion
Our results suggest that HAdV-D36 is related to non-coding RNAs implicated in adipogenesis, representing a potential mechanism by which previous HAdV-D36 infection could be associated with the long-term maintenance of adipogenic status, probably through the GAS5/miR-18a axis.
Study context
- Population
- Individuals with and without obesity undergoing elective, clinically indicated surgery (bariatric or cholecystectomy), with visceral adipose tissue (VAT) biopsies
- Participants
- 29 / 28 / 17
- Exposure
- HAdV-D36 seropositive vs seronegative subjects with obesity
- HAdV-D36[+]n = 29
- HAdV-D36[-]n = 28reference
- Controln = 17
- Outcome
- Expression of lncRNAs (ADINR, GAS5, MEG3) and miRNAs (miR-18a, miR-140) in visceral adipose tissue by qPCR
Main finding
As reported in the abstract
Expression of non-coding RNAs in VAT
Inverse correlation of GAS5 with PPARG expression (r)
−0.917
p = 0.01
Observational data: associations, not effects.
Original publication
Adenovirus 36 seropositivity is related to the expression of anti-adipogenic lncRNAs GAS5 and MEG3 in adipose tissue obtained from subjects with obesity. Int J Obes (Lond). Published 19 June 2024. doi:10.
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