Is severe carbohydrate restriction necessary for appetite suppression? The ASKED randomized controlled trial
Authors' conclusion
Although the findings of this trial are not definitive, changes in hunger ratings with weight loss did not differ among groups. Additional studies with CHO intake of up to 130 g in 1000-kcal/day LEDs are warranted to replicate these findings.
Study context
- Population
- Adults with obesity (BMI, mean [SEM], 34.7 [0.4] kg/m²); 8 weeks LED, then 4 weeks refeeding and weight stabilization51 female
- Participants
- 101 adults
- Comparison
- Low vs medium vs high CHO 1000 kcal/day low-energy diets (LEDs)
Methodological detailsthree-arm, isocaloric low-energy diets
- Three-arm
- Isocaloric low-energy diets
Primary result
As reported in the abstract
βHB concentration (ketosis) · week 8
Difference, mM (95% CI)P value
Low CHOvs Medium CHOSEM 0.09
−0.40(−0.67 to −0.09)
P < 0.001Low CHOvs High CHOSEM 0.10
−0.644(−0.84 to −0.44)
P < 0.001Medium CHOvs High CHOSEM 0.08
−0.15(−0.30 to 0.002)
P = 0.054Further findings
| Outcome | Difference (mm) (95% CI) | P value | |
|---|---|---|---|
| Hunger · week 8Low CHOvs Medium CHOSEM 7.36; second Lowvs Medium comparison as printed | 7.74 (−6.77 to 22.26) | P = 0.294 | |
| Hunger · week 8Medium CHOvs High CHOSEM 7.48 | −3.13 (−17.89 to 11.63) | P = 0.676 | |
| −20−100102030Difference, mm (linear scale) |
| Outcome | Difference (kg) (95% CI) | P value | |
|---|---|---|---|
| Weight loss (BW) · week 8Low CHOvs Medium CHOSEM 0.95 | 2.32 (0.44–4.21) | P = 0.016 | |
| Weight loss (BW) · week 8Low CHOvs High CHOSEM 0.96 | 2.29 (0.39–4.19) | P = 0.016 | |
| Weight loss (BW) · week 8Medium CHOvs High CHOSEM 0.94 | −0.03 (−1.89 to 1.84) | P = 0.977 | |
| −20246Difference, kg (linear scale) |
| Outcome | Difference (mm) (95% CI) | P value |
|---|---|---|
| Hunger · week 8Between Low CHO and Medium CHO · SEM 5.92 | −10.87 (−0.82 to 22.57) | P = 0.068 |
Hunger · week 8
- No significant differences in hunger among groups
Original publication
Is severe carbohydrate restriction necessary for appetite suppression? The ASKED randomized controlled trial. Obesity (Silver Spring). Published 15 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →