Trajectories of fasting glucose and glycated haemoglobin in obese and non‐obese incident diabetes: Results from two large cohort studies
Authors' conclusion
Obese and non-obese diabetes developments may share a similar FPG but distinct HbA1c trajectory. Obese diabetes interventions require more attention to cardiometabolic risks. Moreover, studies addressing weight/sex-related differences in diabetes aetiologies and treatments are warranted.
Study context
- Population
- Participants without diabetes and BMI 18.5–40 kg/m² at baseline, China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA); incident diabetes (mean age 61.4 years; male 46.2%)1,361 incident diabetes
- Participants
- 11,925 participants
- Exposure
- Obese vs non-obese incident diabetes
- Outcome
- Difference in FPG/HbA1c trajectory before T2D diagnosis by obesity status
- Follow-up
- Within 15 years
Methodological detailsmixed-effects models
- Mixed-effects models
Main finding
As reported in the abstract
- SE = 0.642; non-significant
- Fasting plasma glucose (FPG) slope difference (CHARLS) 0.149 mg/dl; P = 0.816
- SE = 0.013; non-significant
- FPG slope difference (ELSA) 0.013 mg/dl; P = 0.337
- SE = 0.016; steeper increase with obese diabetes
- HbA1c slope difference (CHARLS) 0.036 %; P = 0.021
- SE = 0.014; steeper increase with obese diabetes
- HbA1c slope difference (ELSA) 0.032 %; P = 0.027
Observational data: associations, not effects.
Further findings
Cardiometabolic risk at diagnosis
- Obese diabetes showed higher diastolic blood pressure and C-reactive protein at diagnosis than non-obese diabetes
HbA1c trajectory by sex
- Difference in HbA1c trajectory by weight status only significant in males
- Sex-stratified analyses
Original publication
Trajectories of fasting glucose and glycated haemoglobin in obese and non‐obese incident diabetes: Results from two large cohort studies. Diabetes Obes Metab. Published 19 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →