Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls
Authors' conclusion
SCT and SCTR mRNA expression and S-cell density were abundant in the duodenum and decreased along the small intestine. Very low SCT and SCTR mRNA levels and S-cell numbers were observed in the large intestine, without aberrations in individuals with T2D compared to healthy controls.
Study context
- Population
- Individuals with T2D and healthy controls; intestinal mucosa biopsies along the small intestine at 30-cm intervals and from 7 sites along the large intestine
- Participants
- 12 vs 12
- Comparison
- T2D vs healthy controls
- T2Dn = 12
- Healthy controlsn = 12reference
- Outcome
- SCT and SCTR mRNA expression and S-cell density along the intestinal tract
Methodological detailsimmunohistochemistry and messenger RNA (mRNA) sequencing, double-balloon enteroscopy
- Immunohistochemistry and mRNA sequencing
- Double-balloon enteroscopy
Main finding
As reported in the abstract
Reduction in ileum vs duodenum (reference): Secretin (SCT) mRNA, SCT receptor (SCTR) mRNA, S-cell density, respectively
14, 100, and 50 times
Original publication
Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls. J Clin Endocrinol Metab. Published 19 June 2023. doi:10.
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