Crosstalk between genetic variability of adiponectin and leptin, glucose‐insulin system and subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study 14
Authors' conclusion
Results of this study reinforce knowledge on adipokines' role in regulating glucose metabolism; in particular highlighted the potential atherogenic role of leptin and the anti atherogenic role of adiponectin.
Study context
- Population
- Patients with newly diagnosed T2D (Verona Newly Diagnosed Type 2 Diabetes Study)
- Participants
- 794 patients
- Outcome
- Associations of ADIPOQ, LEP and LEPR genetic variability with glucose-insulin system and subclinical atherosclerosis (ATS)
Methodological detailsEuglycemic hyperinsulinemic clamp (insulin sensitivity); modelling of 5h-OGTT (β-cell function); resting ECG; carotid and lower limb artery eco-doppler (atherosclerosis (ATS)); genotyping of tag-SNPs in ADIPOQ, leptin (LEP) and leptin receptor (LEPR)
- Euglycemic hyperinsulinemic clamp (insulin sensitivity); modelling of 5h-OGTT (β-cell function); resting ECG; carotid and lower limb artery eco-doppler (ATS); genotyping of tag-SNPs in ADIPOQ, LEP and LEPR
Main finding
As reported in the abstract
- ADIPOQ-GAACA haplotype: plasma adiponectin
- p=0.034; β=−0.24
- ADIPOQ-GAACA haplotype: ECG abnormalities
- p=0.012; OR=2.76
- ADIPOQ-GAACA haplotype: carotid ATS
- p=0.025; OR=2.00
- ADIPOQ-GAACA haplotype: peripheral limb artery ATS
- p=0.032; OR=1.90
- LEP-CTA haplotype: ischemic ECG abnormalities
- p=0.017; OR=2.24
- LEPR-GAACGG: circulating leptin
- p=0.005; β=−0.31
- LEPR-GAACGG: worst β-cell function
- p=0.023; β=−15.10
Observational data: associations, not effects.
Further findings
Adiponectin levels: negative association with BMI, WHR and TG; positive with HDL and insulin sensitivity
- Regression analyses
- p-all<0.03
Leptin levels: positive association with BMI, HDL-C and plasma TG; negative with insulin sensitivity
- Regression analyses
- p-all<0.001
Original publication
Crosstalk between genetic variability of adiponectin and leptin, glucose‐insulin system and subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study 14. Diabetes Obes Metab. Published 19 June 2023. doi:10.
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