Real‐world study of ethnic differences in glycaemic control and clinical characteristics among insulin‐naïve people with type 2 diabetes initiating biphasic insulin aspart 30/70: A retrospective, observational cohort study in England
Authors' conclusion
Among insulin-naïve people with T2D initiating BIAsp 30, clinically meaningful HbA1c reductions in all ethnicities were observed. Some ethnic groups had larger reductions than others, but differences were small. In all groups, small BMI increases were seen, with small differences observed between groups. Hypoglycaemia rates were low.
Study context
- Population
- Insulin-naïve adults with T2D initiating biphasic insulin aspart 30/70 (BIAsp 30) in primary practice in England
- Participants
- 11,186 adults
- Exposure
- Ethnic groups initiating BIAsp 30
- Whiten = 9,443
- South Asiann = 1,116
- Blackn = 594
- Chinesen = 33
- Outcome
- Change in HbA1c and body mass index (BMI)
- Follow-up
- 6 months post index
Methodological detailsobservational, Clinical Practice Research Datalink Aurum database
- Observational
- Clinical Practice Research Datalink Aurum database
Main finding
As reported in the abstract
White
−2.32
95% CI −2.36–-2.28 · %-points
South Asian
−1.91
95% CI −2.02–-1.80 · %-points
Black
−2.55
95% CI −2.69–-2.40 · %-points
Chinese
−2.64
95% CI −3.24–-2.04 · %-points
Observational data: associations, not effects.
Further findings
kg/m²
| Outcome | White | South Asian | Black | Chinese |
|---|---|---|---|---|
| Estimated change in BMI · 6 months post index | 0.92 (95% CI 0.86–0.99) | 0.60 (95% CI 0.41–0.78) | 1.41 (95% CI 1.16–1.65) | 0.32 (95% CI −0.67–1.30) |
Safety
Hypoglycaemic event rate, overall population
Events per 100 patient-years
- Before index
- 0.92
- Post index
- 3.37
- Event numbers too low to be analysed by subgroup
Original publication
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