Distribution of Somatostatin and Its Receptors in the Intestinal Tract in Healthy Patients and Patients with Type 2 Diabetes
Authors' conclusion
Somatostatin-positive cells as well as somatostatin and SSTR1 mRNA expression are abundant in the mucosa through the entire human intestinal tract, and no differences between healthy individuals and patients with type 2 diabetes were observed. mRNA expression levels of SSTR2-5 are low and SSTR4 undetectable in the human intestinal tract.
Study context
- Population
- Patients with T2D and age- and BMI-matched nondiabetic individuals; mucosal biopsies along the entire small intestine (30 cm intervals) by double-balloon enteroscopy and from 7 defined regions (duodenum, Treitz ligament, ileocecal transition, large intestine)
- Participants
- 12 vs 12
- Comparison
- T2D vs nondiabetic individuals
- T2Dn = 12
- Nondiabeticn = 12reference
- Outcome
- Somatostatin-positive cells and somatostatin/SSTR1-5 mRNA along the intestinal tract
Methodological detailsage- and BMI-matched
- Age- and BMI-matched
Main finding
As reported in the abstract
- Somatostatin-positive mucosal cells throughout the intestinal tract in both groups, highest density in proximal small intestine and rectum, matching somatostatin mRNA profiles
- SSTR1 abundantly expressed, decreasing along the small intestine; uniform, low expression through the large intestine
- Low SSTR2, SSTR3 and SSTR5 mRNA and no SSTR4 mRNA along the intestinal tract in both groups
- No significant differences between groups for cell density or mRNA expression
Original publication
Distribution of Somatostatin and Its Receptors in the Intestinal Tract in Healthy Patients and Patients with Type 2 Diabetes. J Clin Endocrinol Metab. Published 11 December 2025. doi:10.
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