Expression of Bile Acid Receptors and Transporters Along the Intestine of Patients With Type 2 Diabetes and Controls
Authors' conclusion
We demonstrate distinct expression patterns of bile acid transporters and receptors through the intestinal tract with signs of reduced ASBT, OSTα/β, FXR, and FGF19 mRNAs in T2D.
Study context
- Population
- Individuals with T2D and matched healthy controls; intestinal mucosa biopsies sampled along the intestinal tract
- Participants
- 12 vs 12
- Comparison
- T2D vs healthy controls
- T2Dn = 12
- Healthy controlsn = 12reference
- Outcome
- Intestinal expression of bile acid transporters and receptors
Methodological detailsmatched healthy controls, messenger RNA (mRNA) sequencing of intestinal mucosa biopsies
- Matched healthy controls
- mRNA sequencing of intestinal mucosa biopsies
Main finding
As reported in the abstract
- ASBT and OSTα/β expressed in duodenum of both groups, increasing through the small intestine; no (ASBT) or decreasing (OSTα/β) levels through the large intestine
- Farnesoid X receptor (FXR) expression pattern followed that of OSTα/β; FGFR4 evenly expressed through the intestines
- Negligible levels of TGR5 and FGF19
- T2D had lower FGF19, FXR, ASBT and OSTα/β mRNAs vs healthy controls; not statistically significant after adjusting for multiple testing
Original publication
Expression of Bile Acid Receptors and Transporters Along the Intestine of Patients With Type 2 Diabetes and Controls. J Clin Endocrinol Metab. Published 18 April 2024. doi:10.
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