Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardiac MRI
Main finding · Composite endpoint (HF readmission, cardiovascular mortality, heart transplantation)Result — go to the resultHazard ratio 3.03 95% CI 1.39–6.63Authors' conclusion
SO is a potentially high-risk phenotype with adverse LV remodeling and poor clinical outcomes in diabetic patients with HFrEF that may require more attention.
Study context
- Population
- Patients with HF with reduced ejection fraction (HFrEF) and diabetic mellitus (DM) who underwent cardiac MRI
- Participants
- 283 patients
- Exposure
- Sarcopenic obesity vs neither sarcopenia nor obesity
- Outcome
- Composite of:
- Heart failure (HF) readmission
- Cardiovascular mortality
- Heart transplantation
- Follow-up
- Median 35.1 months
Methodological detailscardiac MRI
- Cardiac MRI
Main finding
As reported in the abstract
Composite endpoint:
- HF readmission
- Cardiovascular mortality
- Heart transplantation
Hazard ratio
3.03
95% CI 1.39–6.63
P = 0.005
SOvs Neither sarcopenia nor obesity
HR 3.03 (95% CI 1.39–6.63); P = 0.005
- Patients reaching the composite endpoint (all)
- 73 (25.8%)
Observational data: associations, not effects.
Further findings
Clinical profile: NT-proBNP and hypoproteinemia
- Sarcopenic obesity (SO) had greater NT-proBNP and were more likely than nonsarcopenic patients with obesity to present with hypoproteinemia
Left ventricular (LV) remodeling among patients with obesity
- Sarcopenia displayed greater LV expansion, more profound LV dysfunction and increased LV mass
Original publication
Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardiac MRI. Cardiovasc Diabetol. Published 17 February 2025. doi:10.
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