Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes
Authors' conclusion
Ectopic fat distribution is more strongly associated with CAN in AD than in T2D. This highlights the distinct role of fat distribution in the cardiometabolic health of people with AD, suggesting the need for further studies to better understand the pathophysiology and implications of overweight in this population.
Study context
- Population
- People with diabetes undergoing clinical screening for cardiac autonomic neuropathy (CAN); body fat distribution by DXA
- Participants
- 143 people
- Exposure
- CAN vs no CAN, by diabetes type
- Autoimmune diabetes (AD)n = 44
- T2Dn = 99reference
- Outcome
- Association of CAN with markers of ectopic fat distribution and its interaction with diabetes type
Methodological detailsmultivariate regression adjusted for confounders, interaction testing
- Multivariate regression adjusted for confounders
- Interaction testing
Main finding
As reported in the abstract
Ectopic fat markers by CAN status, in AD
Significant interaction between CAN and diabetes type for ectopic fat markers; differences in AD but not in T2D
p-values for interaction < 0.05 for all comparisons
Observational data: associations, not effects.
Original publication
Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes. Cardiovasc Diabetol. Published 14 February 2025. doi:10.
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