Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth Study
Authors' conclusion
Arterial stiffness is related to and predicts microvascular complications in youth-onset type 1 and type 2 diabetes.
Study context
- Population
- Adolescents and young adults with youth-onset T1D or T2D, SEARCH for Diabetes in Youth Study; median age at initial visit 18 years, 58% female
- Participants
- 1,226 adolescents
- Outcome
- Association of AIx with microvascular complications (cross-sectional)
Methodological detailscross-sectional and longitudinal analyses, follow-up once at ∼5 years
- Cross-sectional and longitudinal analyses
- Follow-up once at ∼5 years
Main finding
As reported in the abstract
- T1D: any one microvascular complication, OR
- 1.35 (1.04-1.76) (95% CI)
- T1D: microalbuminuria, OR
- 2.76 (1.78-4.39) (95% CI)
- T1D: neuropathy, OR
- 1.63 (1.07-2.50) (95% CI)
- T1D: retinopathy, OR
- 1.37 (1.06-1.79) (95% CI)
- T2D: microalbuminuria, OR
- 2.05 (1.04-4.33) (95% CI)
Observational data: associations, not effects.
Further findings
Change in augmentation index (AIx) and development of microvascular complications (longitudinal) · ∼5 years
- T1D: any one microvascular complication, OR
- 1.45 (1.15-1.82) (95% CI)
- T1D: microalbuminuria, OR
- 5.42 (1.98-14.80) (95% CI)
- T1D: neuropathy, OR
- 2.03 (1.22-3.40) (95% CI)
- T1D: retinopathy, OR
- 1.48 (1.15-1.90) (95% CI)
- T2D: microalbuminuria, OR
- 21.98 (1.30-372.88) (95% CI)
- All P < 0.05
Original publication
Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth Study. Diabetes Care. Published 14 February 2025. doi:10.
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