Association of a Lifestyle Risk Index With Visceral and Subcutaneous Adipose Tissue in the German National Cohort ( NAKO )
Authors' conclusion
A combination of lifestyle factors appears to be associated with lower VAT volume, but an elevated BMI may have a greater influence on VAT accumulation than lifestyle behaviors alone.
Study context
- Population
- German National Cohort (NAKO) participants with whole-body magnetic resonance imaging (MRI); aged 48.2 ± 12.2 years
- Participants
- 18,508 participants
- Exposure
- LSRI score 4 vs 0/1
- Outcome
- Adjusted geometric mean VAT volume (whole-body MRI at 3T, deep learning segmentation)
- Follow-up
- Baseline
Main finding
As reported in the abstract
Adjusted geometric mean VAT volume
Observational data: associations, not effects.
Further findings
Distribution of LSRI points (0/1, 2, 3, 4)
Visceral adipose tissue (VAT) after adjustment for BMI, and by BMI stratum
- Differences slightly attenuated after adding BMI
- Association weaker in obesity than normal/overweight
Original publication
Association of a Lifestyle Risk Index With Visceral and Subcutaneous Adipose Tissue in the German National Cohort ( NAKO ). Obesity (Silver Spring). Published 19 November 2025. doi:10.
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