Obesity

Effects of hypoxic training interventions on cardiometabolic health of adults with overweight and obesity: A systematic review and meta‐analysis

Diabetes Obes MetabPublished Systematic review and meta-analysis of randomised trials

An erratum to this article was published (Diabetes Obes Metab, Oct 2026 ↗)

Authors' conclusion

Hypoxic training did not outperform normoxic training in improving cardiometabolic outcomes.

Study context

Population
Adults with overweight or obesity; RCTs from PubMed, Web of Science and Cochrane Library (up to June 2025)
Participants
278 adults9 RCTs
Comparison
Hypoxic vs normoxic training
Outcome
Fasting glucose and fasting insulin
Methodological detailssubgroup, moderation and sensitivity analyses
  • Subgroup, moderation and sensitivity analyses

Pooled result

As reported in the abstract

Heterogeneity (I2)

60%-77%

Further pooled results

OutcomeP value
Lipid profile markers and blood pressureNo significant between-group differences · moderate to high heterogeneityall p > 0.05

Subgroup and moderation analyses

Greater fasting glucose reductions suggested with shorter and lower-intensity hypoxic interventions

Original publication

Effects of hypoxic training interventions on cardiometabolic health of adults with overweight and obesity: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 18 November 2025. doi:10.1111/dom.70303

Composed by AI from the published abstract and checked against it. How Briefs are made →

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