Association of Obesity Severity With Cardiometabolic and Renal Disease Burden in the United States
Authors' conclusion
Obesity severity is incrementally associated with cardiometabolic and renal disease burden, particularly among adults with BMI ≥ 50 kg/m2. These findings highlight the urgent need for early, aggressive interventions targeting individuals with all classes of obesity.
Study context
- Population
- US adults, Behavioral Risk Factor Surveillance System (BRFSS), 2011–2023
- Exposure
- Increasing BMI categories
- Outcome
- Diagnosis of diabetes, hypertension, hyperlipidemia, kidney disease, MI, stroke and coronary artery disease
Methodological detailssurvey-weighted logistic regression
- Survey-weighted logistic regression
Main finding
As reported in the abstract
- Diabetes, BMI ≥ 50 kg/m²
- OR 8.32; 95% CI: 7.78-8.91
- Hypertension, BMI ≥ 50 kg/m²
- OR 6.07; 95% CI: 5.58-6.61
- Kidney disease, BMI ≥ 50 kg/m²
- OR 3.60; 95% CI: 3.21-4.03
- MI, BMI ≥ 50 kg/m²
- OR 2.89; 95% CI: 2.56-3.28
- Coronary artery disease, BMI ≥ 50 kg/m²
- OR 3.44; 95% CI: 3.08-3.84
Observational data: associations, not effects.
Further findings
Mean age at diabetes diagnosis
Mean age at diabetes diagnosis
- Decreased with increasing BMI
Original publication
Association of Obesity Severity With Cardiometabolic and Renal Disease Burden in the United States. Obesity (Silver Spring). Published 18 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →