Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens
Authors' conclusion
Despite producing substantial amounts of A4 and T, human gonads are not relevant sources of 11-oxyandrogens.
Study context
- Population
- 11 patients (7 women) undergoing gonadal venograms, median age 37 (range, 31–51 years); 17 women, median age 57 (range, 41–81 years), undergoing bilateral salpingo-oophorectomy (BSO)11 venogram + 17 BSO pts
- Participants
- 11 / 11 / 17 / 17
- Comparison
- Gonadal vs peripheral vein steroids; before vs after bilateral salpingo-oophorectomy (BSO)
- Gonadal veinn = 11
- Peripheral veinn = 11reference
- Before BSOn = 17reference
- After BSOn = 17
- Outcome
- Gonadal contribution to the circulating pool of 11-oxyandrogens (13 steroids measured by LC-MS/MS)
Methodological detailspaired gonadal and peripheral vein sampling, before-after BSO comparison, LC-MS/MS steroid profiling
- Paired gonadal and peripheral vein sampling
- Before-after BSO comparison
- LC-MS/MS steroid profiling
Main finding
As reported in the abstract
11-oxyandrogens
- Four 11-oxyandrogens were similar between matched gonadal and peripheral vein samples
- 11-oxyandrogens remained stable after BSO
Further findings
| Outcome | P value |
|---|---|
| Traditional steroids in gonadal vs peripheral veins | P < 0.05 for all |
- Traditional steroids in gonadal vs peripheral veins: A4, T, estradiol, estrone, progesterone, 17α- and 16α-hydroxyprogesterone all higher in gonadal veins
A4 and T after BSO
- A4 declined after BSO
- P < 0.001
- T declined after BSO
- P < 0.001
CYP11B1 mRNA expression in gonadal tissue
- Gonadal tissue displayed negligible CYP11B1 mRNA
Original publication
Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens. J Clin Endocrinol Metab. Published 17 June 2024. doi:10.
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