High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas
Authors' conclusion
Patients with overt, mild, and even absent cortisol excess demonstrate lipoprotein profile abnormalities, in particular, high LDLP and ApoB concentrations, which conceivably contribute to high cardiometabolic risk.
Study context
- Population
- Patients with NFA, mild autonomous cortisol secretion (MACS) or Cushing syndrome (CS) and referent individuals, January 2015 to July 2022; lipoproteins measured by nuclear magnetic resonance spectroscopy
- Participants
- 167 / 213 / 142 / 202
- Exposure
- NFA, MACS and CS vs referent individuals
- NFAn = 167
- MACSn = 213
- CSn = 142
- Referent individualsn = 202reference
- Outcome
- Extent of lipoprotein abnormalities (TRLP, LDLP, high-density lipoprotein particles (HDLP), subclasses and sizes)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Very large triglyceride-rich lipoprotein particles (TRLP), large TRLP and TRLP size increased in all patient categories, age- and sex-adjusted (OR range)
1.22-2.08
Total low-density lipoprotein particles (LDLP) increased in all patient categories, age- and sex-adjusted (OR range)
1.22-1.75
LDLP remained elevated in all patient categories, fully adjusted (OR range)
1.31-1.84
Observational data: associations, not effects.
Further findings
Total cholesterol, LDL-C, TG and apolipoprotein B (ApoB)
- Total cholesterol, LDL-C, TG and ApoB higher in all patient categories, age- and sex-adjusted; ApoB remained elevated in fully adjusted analysis
LDLP and ApoB excluding individuals on lipid-lowering therapy
- Similar LDLP and ApoB elevations in all patient categories
Original publication
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