Hip fractures in patients with primary aldosteronism – a Swedish nationwide study
Main finding · Hip fractureResult — go to the resultAdjusted hazard ratio 1.55 CI 1.18–2.03Authors' conclusion
PA is associated with increased hip fracture risk, especially in women, patients diagnosed after the age of 56 years and patients with established CVD at diagnosis.
Study context
- Population
- Nationwide Swedish cohort of patients with primary aldosteronism (1997–2019) and matched general-population controlsmean follow up 8 ± 5 years
- Participants
- 2,419 vs 24,187
- Exposure
- Primary aldosteronism vs age and sex matched controls from the general population
- Primary aldosteronism (PA)n = 2,419
- Controlsn = 24,187reference
- Outcome
- Incident hip fracture (ICD codes, Swedish National Patient Register)
Methodological detailsnationwide, age and sex matched controls, adjusted hazard ratios (HRs)
- Nationwide
- Age and sex matched controls
- Adjusted HRs
Main finding
Hip fracture · mean follow up 8 ± 5 years
Adjusted hazard ratio
1.55
CI 1.18–2.03
Events by group
PAvs Controls
adjusted HR 1.55 (CI 1.18–2.03)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Hip fracture in women (subgroup) | 1.76 (1.24–2.52) | |
| Hip fracture in patients aged > 56 years (subgroup) | 1.62 (1.21–2.17) | |
| Hip fracture in patients with CVD at diagnosis (subgroup) | 2.15 (1.37–3.37) | |
| Hip fracture in PA treated with adrenalectomy (subgroup) | 0.84 (0.35–2.0) | |
| Hip fracture in PA treated with MRA (subgroup) | 1.84 (1.20–2.83) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Hip fractures in patients with primary aldosteronism – a Swedish nationwide study. Osteoporos Int. Published 5 June 2024. doi:10.
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