Impact of diagnosis and targeted interventions on the quality of life and neuropsychiatric outcomes of patients with adrenal tumours: a systematic review
Authors' conclusion
Adrenal tumours are associated with substantial and often persistent impairment in patient well-being across tumour subtypes. Although treatment generally improves outcomes, residual symptoms are common, underscoring the need for long-term, patient-centred care and for the development of adrenal tumour-specific patient-reported outcome measures.
Study context
- Population
- Adults with adrenal tumours (non-functioning adrenal tumours (NFAT), mild autonomous cortisol secretion (MACS), adrenal Cushing's syndrome (CS), primary aldosteronism (PA), PPGL, adrenocortical carcinoma (ACC)); MEDLINE, Embase, Cochrane Library, CINAHL, January 1990-March 2026
- Participants
- 35,361 adults117 studies
- Outcome
- Impact of adrenal tumour diagnosis and targeted interventions on HRQoL and neuropsychiatric outcomes
Methodological detailsnarrative synthesis, Quality assessed with CONSORT-PRO and Newcastle-Ottawa criteria; narrative synthesis due to methodological heterogeneity
- Narrative synthesis
- Quality assessed with CONSORT-PRO and Newcastle-Ottawa criteria; narrative synthesis due to methodological heterogeneity
Pooled result
As reported in the abstract
HRQoL and neuropsychiatric outcomes
- Across tumour subtypes, adrenal tumours consistently associated with impaired health-related quality of life (HRQoL) and neuropsychiatric outcomes
- Gradient of burden: mild impairment in NFAT, intermediate in MACS and PA, most pronounced and persistent deficits in adrenal CS, PPGL and ACC
- Targeted interventions often associated with improved patient-reported outcomes; magnitude and consistency varied across subtypes and study design
- Recovery frequently incomplete
Further pooled results
Instruments used
- Most studies relied on generic HRQoL instruments; no disease-specific neuropsychiatric tools identified
Study quality
- CONSORT-PRO quality good but heterogeneous; observational study quality mostly moderate or low
Original publication
Impact of diagnosis and targeted interventions on the quality of life and neuropsychiatric outcomes of patients with adrenal tumours: a systematic review. Eur J Endocrinol. Published 21 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →