Inflammation-based scores in benign adrenocortical tumours are linked to the degree of cortisol excess: a retrospective single-centre study
Authors' conclusion
Neutrophil-to-lymphocyte ratio, SII, and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.
Study context
- Population
- Patients with benign adrenocortical tumours with different degrees of cortisol excess
- Participants
- 375 patients
- Exposure
- Mild autonomous cortisol secretion (MACS) and Cushing's syndrome (CS) vs non-functioning adrenal tumours (NFAT)
- NFATn = 215reference
- MACSn = 138
- CSn = 22
- Outcome
- Haematological alterations: full blood count and inflammation-based scores (neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), SII)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Full blood count and inflammation-based scores
- Gradual and significant increase of leucocytes, neutrophils and monocytes from NFAT over MACS to CS
- MACS vs NFAT: P < 0.001
- CS vs NFAT: P = 0.002
- MACS vs NFAT: P = 0.006
- CS vs NFAT: P = 0.021
- MACS vs NFAT: P = 0.01
- CS vs NFAT: <.001
- CS vs MACS: P = 0.007
Observational data: associations, not effects.
Original publication
Inflammation-based scores in benign adrenocortical tumours are linked to the degree of cortisol excess: a retrospective single-centre study. Eur J Endocrinol. Published 14 November 2023. doi:10.
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