Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study
Authors' conclusion
Patients with functioning and nonfunctioning adrenal masses demonstrated increased GlycA and BCAAs, biomarkers associated with adverse cardiometabolic disorders and mortality. Patients with NFA demonstrated an adverse metabolic profile similar to patients with MACS and CS.
Study context
- Population
- Patients with adrenal disorders, single centre, January 2015–July 2022
- Exposure
- Patients with adrenal disorders vs referent individuals
- Referent individualsn = 5,241reference
- Outcome
- GlycA, total BCAAs, ketone bodies, TMAO and betaine measured by nuclear magnetic resonance spectroscopy
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
GlycA, BCAAs, TMAO, betaine and ketone bodies vs referent individuals (age- and sex-adjusted)
- Increased glycoprotein acetylation (GlycA) in all patient categories
- Increased branched-chain amino acids (BCAAs) in NFA, mild autonomous cortisol secretion (MACS), Cushing syndrome (CS), primary aldosteronism (PA) and adrenocortical carcinoma (ACC)
- Increased TMAO in patients with other malignant adrenal masses
- Increased betaine in NFA and MACS
- Increased ketone bodies in NFA, CS and ACC
- Age- and sex-adjusted
Observational data: associations, not effects.
Further findings
Fully adjusted analysis and analysis excluding participants with DM and CVD
- Essentially similar findings
- Adjusted for age, sex, BMI, smoking, hypertension, DM and statin therapy
Original publication
Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study. J Clin Endocrinol Metab. Published 28 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →