Association Between Clinical Factors and Postoperative Hypoglycemia in Pheochromocytoma and Paraganglioma: A Retrospective Cohort Study
Authors' conclusion
Clinical factors were independently associated with the occurrence of postoperative hypoglycemia in PPGL. The visual nomogram developed in this study aided in predicting the risk of postoperative hypoglycemia in PPGL patients.
Study context
- Population
- Adults who underwent pheochromocytoma and paraganglioma (PPGL) surgery with pathologic confirmation
- Participants
- 346 adults
- Outcome
- Occurrence of postoperative hypoglycemia
Main finding
As reported in the abstract
Postoperative hypoglycemia
Postoperative hypoglycemia
45 patients
13.0%
Occurring within 24 h after surgery
35 cases
83.3%
Observational data: associations, not effects.
Further findings
Independent risk factors for postoperative hypoglycemia (multivariate analysis)
- Age <30 years: OR 3.091, 95% CI 1.145-8.344, P= .026
- History of CKD: OR 3.253, 95% CI 1.213-8.725, P= .019
- Preoperative typical symptoms (≥1 of headaches, palpitations, sweating): OR 2.207, 95% CI 1.119-4.355, P= .022
- Preoperative positive semi-quantitative urine glucose: OR 2.986, 95% CI 1.063-8.390, P= .038
- Adrenal tumor: OR 3.224, 95% CI 1.208-8.604, P= .019
Predictive model discrimination
- AUC of predictive model
- 0.734 (95% CI 0.659-0.809)
- Calibration plots suggested good consistency between predicted and actual risk
Original publication
Association Between Clinical Factors and Postoperative Hypoglycemia in Pheochromocytoma and Paraganglioma: A Retrospective Cohort Study. Endocr Pract. Published 18 April 2026. doi:10.
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