The Role of Active Brown Adipose Tissue in Patients With Pheochromocytoma or Paraganglioma
Authors' conclusion
The demethylated metabolite levels could have potential use in predicting the presence of active brown adipose tissue in patients with PPGL. There is no convincing evidence of increased aBAT prevalence in patients with PPGL and germline mutations. There was, however, evidence suggesting that the presence of aBAT may confer poorer outcomes and decreased life expectancy.
Study context
- Population
- Patients with PPGL who had completed FDG-PET imaging; MEDLINE/PubMed, Embase, SCOPUS searched to 2022-11-26, update check 2024-05-026 studies
- Comparison
- aBAT positive vs aBAT negative
- Outcome
- Prevalence of aBAT in PPGL
Methodological detailsrandom-effects model, inverse variance method, standardized mean differences, meta-analysis of proportions, Quality in Prognostic Studies risk of bias tool
- Random-effects model
- Inverse variance method
- Standardized mean differences
- Meta-analysis of proportions
- Quality in Prognostic Studies risk of bias tool
Pooled result
As reported in the abstract
Proportion of patients with PPGL presenting with aBAT
≈25%
Further pooled results
Isolated demethylated catecholamine levels
- Statistically significant positive difference in aBAT positive vs aBAT negative
Tumor size, tumor burden, germline mutations, location
- No significant differences between aBAT positive and negative
Original publication
The Role of Active Brown Adipose Tissue in Patients With Pheochromocytoma or Paraganglioma. Endocr Pract. Published 16 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →