Positron Emission Tomography Imaging of Pheochromocytoma and Paraganglioma—18F-FDOPA vs Somatostatin Analogues
Authors' conclusion
18F-FDOPA and 68Ga-SSA PET are both sensitive for localizing PPGL. However, 18F-FDOPA is the most sensitive for detecting pheochromocytoma, while 68Ga-SSA is superior to 18F-FDOPA for metastatic sympathetic and head-neck paraganglioma and SDHx-related paraganglioma.
Study context
- Population
- Studies of positron emission tomography (PET) scans in ≥20 individuals with pheochromocytoma and paraganglioma (PPGL) or ≥5 individuals in a rare, well-defined PPGL subgroup70 studies
- Comparison
- 18F-FDOPA PET vs 68Ga-SSA PET
- Outcome
- Diagnostic performance (sensitivity) of the most used PET tracers for PPGL
Methodological detailsliterature review, PubMed search January 2004 to August 2024
- Literature review
- PubMed search January 2004 to August 2024
Pooled result
As reported in the abstract
Sensitivity
- 18F-FDOPA had higher sensitivity for pheochromocytoma than 68Ga-SSA
- Equal sensitivity for metastatic pheochromocytoma
- Similar sensitivity for primary non-SDHx sympathetic and head-neck paraganglioma
- 68Ga-SSA had higher sensitivity for metastatic sympathetic and head-neck paraganglioma and for SDHx-related paraganglioma
- 21 head-to-head comparisons of ≥2 PET tracers
Original publication
Positron Emission Tomography Imaging of Pheochromocytoma and Paraganglioma—18F-FDOPA vs Somatostatin Analogues. J Clin Endocrinol Metab. Published 28 October 2024. doi:10.
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