The Diagnostic Value of 18F-FDG PET/CT Scan in Characterizing Adrenal Tumors
Authors' conclusion
18F-FDG PET/CT had good diagnostic accuracy for characterization of adrenal tumors. The literature, however, is limited, in particular regarding adrenal incidentalomas. Large prospective studies in well-defined patient populations with application of validated cutoff values are needed.
Study context
- Population
- Adults with an adrenal tumor, discovered as adrenal incidentaloma or during staging or follow-up of oncologic patients; studies 2000–202117 studies
- Outcome
- Diagnostic value of 18F-FDG PET/CT in differentiating benign from malignant adrenal tumors
Methodological detailsbivariate random-effects model, QUADAS-2 quality assessment, 79 studies retrieved, 17 met selection criteria, PubMed, EMBASE, Web of Science and Cochrane Library searched, 2000–2021
- Bivariate random-effects model
- QUADAS-2 quality assessment
- 79 studies retrieved, 17 met selection criteria
- PubMed, EMBASE, Web of Science and Cochrane Library searched, 2000–2021
Pooled result
As reported in the abstract
Identifying malignant adrenal tumors
| Group | Pooled sensitivity | Pooled specificity | Pooled diagnostic OR |
|---|---|---|---|
| 18F-FDG PET/CT | 87.3% (95% CI, 82.5%-90.9%) | 84.7% (95% CI, 79.3%-88.9%) | 9.20 (95% CI, 5.27-16.08; P < .01) |
18F-FDG PET/CT
Pooled sensitivity87.3% (95% CI, 82.5%-90.9%)
Pooled specificity84.7% (95% CI, 79.3%-88.9%)
Pooled diagnostic OR9.20 (95% CI, 5.27-16.08; P < .01)
Original publication
The Diagnostic Value of 18F-FDG PET/CT Scan in Characterizing Adrenal Tumors. J Clin Endocrinol Metab. Published 10 March 2023. doi:10.
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