KCNJ5-dependent 68Ga-pentixafor positron emission tomography/computed tomography in primary aldosteronism surgery
Authors' conclusion
68Ga-pentixafor PET/CT provides strong rule-in information when uptake is clearly unilateral.
Study context
- Population
- Patients with primary aldosteronism (PA) who underwent unilateral adrenalectomy and 6-month follow-up (929 consecutive suspected PA screened, November 2021 to February 2025); 83 also underwent adrenal venous sampling (AVS)929 screened
- Participants
- 162 patients
- Exposure
- PET/CT-guided vs AVS-guided pathway for PA surgery
- Outcome
- Clinical and biochemical complete success by PASO criteria
- Follow-up
- 6-month follow-up
Methodological detailssingle-center, consecutive patients, overlap weighting, paired PET/CT-versus-AVS analysis, genotype-stratified analyses
- Single-center
- Consecutive patients
- Overlap weighting
- Paired PET/CT-versus-AVS analysis
- Genotype-stratified analyses
Main finding
As reported in the abstract
Clinical and biochemical complete success (PASO) · 6 months
- Clinical and biochemical complete success did not differ significantly between PET-guided and AVS-guided groups
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Unilateral PET/CT vs AVS in patients with both tests | Unilateral PET/CT 98.2% · PPV 56/57, 98.2% |
- Unilateral PET/CT vs AVS in patients with both tests — AVS-confirmed unilateral PA with negative or bilateral PET findings
- 26 of 82
PET positivity by KCNJ5 status
- KCNJ5-nonmutated patients PET-negative
- 22 of 52
- All KCNJ5-mutated patients in the PET-status cohort were PET-positive
Factors associated with PET positivity
- KCNJ5 mutation and CT lesion size independently associated with PET positivity
SUVmax LI and biochemical complete success
- SUVmax LI associated with biochemical complete success, including within KCNJ5-nonmutated patients
Original publication
KCNJ5-dependent 68Ga-pentixafor positron emission tomography/computed tomography in primary aldosteronism surgery. J Clin Endocrinol Metab. Published 30 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →