Accuracy of Gallium-68 Pentixafor Positron Emission Tomography–Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism
Authors' conclusion
This study found good diagnostic accuracy of gallium-68 pentixafor PET-CT in differentiating UPA from BPA. These findings suggest that gallium-68 pentixafor PET-CT may be used to avoid invasive AVS in some patients with PA.
Study context
- Population
- Patients diagnosed with primary aldosteronism (PA) at a tertiary hospital in China; 43 unilateral PA (UPA), 57 bilateral PA (BPA); median age 49 yearscompleted the study
- Participants
- 100 patients
- Comparison
- Gallium-68 pentixafor positron emission tomography-computed tomography (PET-CT) vs adrenal vein sampling (AVS) for PA subtyping
- Outcome
- Accuracy (AUROC, specificity, sensitivity) of lateralization index based on SUVmax for subtyping PA
Methodological detailssingle-centre, tertiary hospital, AVS as reference standard, Enrollment started November 2021; follow-up ended May 2022
- Single-centre
- Tertiary hospital
- AVS as reference standard
- Enrollment started November 2021; follow-up ended May 2022
Performance
As reported in the abstract
Identification of UPA by lateralization index based on SUVmax at 10 minutes
| Test or model | AUROC | Specificity (cutoff 1.65) | Sensitivity (cutoff 1.65) |
|---|---|---|---|
| Gallium-68 pentixafor PET-CT | 0.90 (95% CI, 0.83-0.97) | 1.00 (95% CI, 0.94-1.00) | 0.77 (95% CI, 0.61-0.88) |
Gallium-68 pentixafor PET-CT
AUROC0.90 (95% CI, 0.83-0.97)
Specificity (cutoff 1.65)1.00 (95% CI, 0.94-1.00)
Sensitivity (cutoff 1.65)0.77 (95% CI, 0.61-0.88)
Further findings
- Diagnostic concordance with AVS — Gallium-68 pentixafor PET-CT
- 90.0%
- Diagnostic concordance with AVS: Traditional CT 54.0%
Correlation of adrenal vein aldosterone-cortisol ratio with adrenal SUVmax at 10 minutes
- Spearman ρ
- 0.26; P < .001
Original publication
Accuracy of Gallium-68 Pentixafor Positron Emission Tomography–Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism. JAMA Netw Open. Published 1 February 2023. doi:10.
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