Comparison of Different Diagnostic Criteria of 68Ga-Pentixafor PET/CT for the Classification of Primary Aldosteronism
Authors' conclusion
Both LI and visual analysis could be used for interpretation the results of 68Ga-Pentixafor PET/CT; nevertheless, visual analysis is more sensitive, and LI is more advantageous in specificity.
Study context
- Population
- Patients with primary aldosteronism (PA) who underwent 68Ga-Pentixafor PET/CT, with unilateral (unilateral PA (UPA)) or bilateral PA (BPA) diagnosed by surgery or AVS; tertiary hospital in China128 UPA, 80 BPA
- Participants
- 208 patients
- Comparison
- Different criteria of 68Ga-Pentixafor PET/CT for PA subtyping: Lateralization index (LI), visual analysis, dominant side SUVmax, dominant side SUVmax adjusted by liver
- Outcome
- Accuracy (AUC, sensitivity, specificity) for diagnosing UPA
Methodological detailsretrospective, single-centre (tertiary hospital, China)
- Retrospective
- Single-centre (tertiary hospital, China)
Performance
As reported in the abstract
Diagnosis of UPA
| Test or model | AUC | Youden index (cutoff 1.50) | Sensitivity (cutoff 1.50) | Specificity (cutoff 1.50) | Sensitivity (cutoff 1.65) | Specificity (cutoff 1.65) | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|
| LI | 0.82 | 0.59 | 0.68 | 0.91 | 0.61 | 0.96 | ||
| Visual analysis | 0.82 | 0.73 | 0.88 | |||||
| Dominant side of SUVmax | 0.72 | |||||||
| Dominant side SUVmax adjusted by liver | 0.71 |
AUC
LI0.82
Visual analysis0.82
Dominant side of SUVmax0.72
Dominant side SUVmax adjusted by liver0.71
Youden index (cutoff 1.50)
LI0.59
Visual analysis— not stated in the abstract
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Sensitivity (cutoff 1.50)
LI0.68
Visual analysis— not stated in the abstract
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Specificity (cutoff 1.50)
LI0.91
Visual analysis— not stated in the abstract
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Sensitivity (cutoff 1.65)
LI0.61
Visual analysis— not stated in the abstract
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Specificity (cutoff 1.65)
LI0.96
Visual analysis— not stated in the abstract
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Sensitivity
LI— not stated in the abstract
Visual analysis0.73
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Specificity
LI— not stated in the abstract
Visual analysis0.88
Dominant side of SUVmax— not stated in the abstract
Dominant side SUVmax adjusted by liver— not stated in the abstract
Original publication
Comparison of Different Diagnostic Criteria of 68Ga-Pentixafor PET/CT for the Classification of Primary Aldosteronism. J Clin Endocrinol Metab. Published 29 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →