Evaluation of Sleep Health in Children With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Authors' conclusion
Our findings suggest that sleep health is impaired in children with CAH and is an important consideration for both clinical practice and future research.
Study context
- Population
- Children and adolescents aged 3 to 18 years with classic CAH, multidisciplinary CAH clinic23 male
- Participants
- 44 children
- Exposure
- Children with CAH vs published community and clinical (sleep disorder) samples and normative data in healthy children
- CAHn = 44
- Outcome
- Sleep health measured by wrist actigraphy (ActiGraph GT3X+ worn 1 week) and validated sleep questionnaires
Methodological detailssingle-centre multidisciplinary CAH clinic
- Single-centre multidisciplinary CAH clinic
Main finding
As reported in the abstract
Actigraphy sleep health vs recommendations and healthy children
- Significantly worse sleep efficiency and increased wake after sleep onset vs healthy children
- P < .05
Observational data: associations, not effects.
Further findings
Awakenings per hour after evening hydrocortisone dose
Per hour
- Average awakenings during first 2 hours after evening hydrocortisone dose
- 1.67
- Average awakenings 4 to 7 hours after the dose
- 3.12
- Corresponding with washout of the evening hydrocortisone dose
Parent-reported sleep questionnaires, 3- to 10-year-olds
- Significantly worse sleep onset delay and decreased sleep duration vs both community and clinical samples
- Significantly more night awakenings vs community sample
Original publication
Evaluation of Sleep Health in Children With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. Published 28 November 2024. doi:10.
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