Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission
Authors' conclusion
Bone material properties remain altered in patients with endogenous CS, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.
Study context
- Population
- Patients with endogenous Cushing's syndrome (CS) in remission (median remission 6 years, range 1 to 41) and matched controls, tertiary referral center, 2019–2021; median age 56.5 years, 48 women
- Participants
- 60 vs 60
- Exposure
- CS patients in remission vs matched controls
- CSn = 60
- Controlsn = 60reference
- Outcome
- Bone material strength index (BMSi) by impact microindentation (OsteoProbe) at the tibia
Methodological detailsage-, sex-, and bone mineral density (BMD)-matched controls, tertiary referral center
- Age-, sex-, and BMD-matched controls
- Tertiary referral center
Main finding
As reported in the abstract
BMSi
CS
76.2
± 6.7
Controls
80.5
± 4.9
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Number of fragility fracturesComparable | P = 0.22 |
Number of fragility fractures
- Patients and controls comparable regarding number of fragility fractures
Correlates of bone material strength index (BMSi) in CS patients
- BMSi negatively correlated with BMI (r)
- −0.354, P = .01
- BMSi not related to presence of fracture, physiological hydrocortisone replacement use, other pituitary insufficiencies or time since remission
Original publication
Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission. J Clin Endocrinol Metab. Published 20 November 2024. doi:10.
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