Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism: a cohort study
Main finding · LVHResult — go to the resultOdds ratio 2.0 95% CI 1.23–3.25Authors' conclusion
Patients with PA who smoke have a higher prevalence of LVH and MACS and larger adrenal nodule/s than non-smokers. Smoking has no significant effect on the probability of hypertension response after adrenalectomy in patients with PA; however, a tendency to a lower probability of hypertension cure is observed in smokers compared to non-smokers.
Study context
- Population
- Patients with PA evaluated in 36 Spanish tertiary hospitals with available information on smoking habits
- Participants
- 881 patients
- Exposure
- Smokers vs non-smokers
- Smokersn = 180
- Non-smokersn = 701reference
- Outcome
- Left ventricular hypertrophy (LVH)
- Follow-up
- At diagnosis
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Odds ratio
2.0
95% CI 1.23–3.25
Smokersvs Non-smokers
OR 2.0 (95% CI 1.23–3.25)
Observational data: associations, not effects.
Further findings
Severe LVH
P = 0.164
Hypertension cure · tended to be more frequent with non-smokers
P = 0.076
Tumour size of adrenal nodule/s
P = 0.002
| Outcome | Estimate | |
|---|---|---|
| MACS | OR 2.1 (95% CI 1.14–4.06) | |
| MACSAdjusted for size of adrenal nodule/s | aOR 1.6 (95% CI 0.76–3.37) | |
| 0.20.5125Ratio (log scale) |
Biochemical and hypertension cure after adrenalectomy
- Rate of biochemical and hypertension cure similar in both groups
Original publication
Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism: a cohort study. Eur J Endocrinol. Published 18 November 2024. doi:10.
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